Dr. Matthew Warman is Professor of Genetics and Orthopaedic Surgery at Harvard Medical School, Boston. He also serves as the Director of the Orthopaedic Research Laboratories at Boston Children’s Hospital. Dr. Warman received a Sc.B. in Engineering from Brown University in Rhode Island and an M.D. from Cornell University in New York. He was fortunate to have received excellent mentoring during his scientific training with Drs. Adele Boskey and Bjorn Olsen. Dr. Warman’s research focuses on patients with genetic diseases that affect the skeleton. He and members of his lab have contributed to the identification of disease-causing genes for Mendelian disorders, including Stickler syndrome, Boston-type Craniosynostosis, Metachondromatosis, Achondrogenesis type 1A, and Camptodactyly-Arthropathy-Coxa Vara-Pericarditis syndrome. His lab’s discovery that mutations in the Wnt co-receptor LRP5 cause the autosomal recessive skeletal fragility disorder Osteoporosis-Pseudoglioma syndrome highlighted the importance of WNT signaling in skeletal growth and homeostasis. Current projects in the lab include studying non-heritable genetic skeletal diseases, such as the CLOVES and Klippel-Trenanay syndromes. Dr. Warman describes the overall goal of his work being the discovery of interventions that can prevent, delay, or reverse consequences of heritable and acquired skeletal diseases. Toward this goal, his lab has generated animal models for several human skeletal diseases and is employing these models to perform “proof of principle” studies testing therapeutic interventions that could then be used in patients. His work is currently supported by grants from the Howard Hughes Medical Institute and the U.S. National Institutes of Health.