MD, PhD, is a neurologist/neuroscientist with the major research interest in neurodegenerative disorders including Parkinson’s disease, Alzheimer’s disease and amyotrophic lateral sclerosis. His research interests are cellular and molecular basis of neuronal injury in these neurodegenerative diseases. Main focuses are genetic and inflammatory mechanisms in Parkinson’s disease (PD). Dr. Le received doctoral degree in Shanghai 2nd Medical University in 1988. He got postdoctoral training in Baylor College of Medicine in 1989, promoted to Assistant Professor in 1993, Associate Professor in 2000 and Professor in 2005 in the same medical school. In 2006, He was appointed as the director of Institute of Neurology, Shanghai JiaoTong University School of Medicine. Since 2013 he has relocated to Dalian Medical University as a distinguished professor and director of center for clinical research on neurological diseases, and vice president of 1st affiliated hospital of Dalian Medical University. He has published over 240 scientific papers in SCI-peer reviewed journals including Nature, Sciences, PNAS, Brain, JAMA, Ann Neurology, and Autophagy, which have been cited over 10,000 times. He has been awarded 26 research grants including 3 NIH R0-1 awards, and 8 grants from Chinese Nature Science Foundation. He is reviewer committee member for NIH, VA, INSERM, Singapore Academy of Science, and Chinese Nature Science Foundation. He has served as the editorial board member or associated editor for 10 international journals.