Holger Willenbring is a Professor in the Department of Surgery, Division of Transplant Surgery and the Associate Director of the Liver Center at the University of California San Francisco (UCSF). He received his degrees from the Medical University Lübeck, Germany and did a residency in pediatrics at the University of Münster, Germany. Prompted by his clinical experience, he did postdoctoral research exploring alternative cell sources for liver cell therapy in the laboratory of Markus Grompe at Oregon Health & Science University. Holger Willenbring’s laboratory in the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF works on developing the scientific basis for new therapies for severe liver diseases. The laboratory is using insights from liver development and liver regeneration to generate transplantable hepatocytes from readily and safely accessible human cells such as fibroblasts. In addition, the laboratory is developing in vivo reprogramming strategies for therapy for liver diseases that can currently only be cured by liver transplantation.