Sun Qiang
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Sun Qiang

Education

2002.9-2005.7      Ph.D., Shanghai Institute of Pharmaceutical Industry 
1996.9-1999.7     M.S., major in experimental animal, College of Veterinary Medicine, Yangzhou University
1992.9-1996.7      B.S., Inner Mongolia University for the nationalities
Work experience
2009.6-Present      Institute of Neuroscience, Chinese Academy of Sciences
2005.9-2009.5      Associate investigator, Institute of Brain Functional Genomics, East China Normal University
1999.8-2005.7      College of Veterinary Medicine, Yangzhou University
Research
1、Construction of transgenic non-human primate models by using lentivirus injection.
2、Construction of genomic modified non-human primate models by Talen, Crisrp-Cas9 methods.
3、Using the testis xenografting method to accelerate the reproduction cycle of non-human primate models.
4、Using the Crispr-Cas9 method to develop more efficient gene knock-out or knock-in Technology.
5、Construction of monkey models by SCNT.
Publications
1)Zhen Liu, Zongyang Lu, Guang Yang, Shisheng Huang, Guanglei Li2, Songjie Feng, Yajing Liu, Jianan Li,Wenxia Yu, Yu Zhang, Jia Chen , Qiang Sun & Xingxu Huang. (2018) Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing. Nature communication, 2018,9:2338.
2)Zhen Liu, Yijun Cai, Yan Wang, Yanhong Nie, Chenchen Zhang, Yuting Xu, Xiaotong Zhang, Yong Lu,
Zhanyang Wang, Muming Poo, and Qiang Sun* (2018) Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer. Cell, advance online. Cell 172, 881–887, February 8, 2018.
3)Xuan Yao, Zhen Liu, Xing Wang, Yan Wang, Yan-Hong Nie, Liang Lai, Ruilin Sun, Linyu Shi, Qiang Sun* & Hui Yang* (2018) Generation of knock-in cynomolgus monkey via CRISPR/Cas9 editing. Cell research,2018, https://doi.org/10.1038/cr.2018.9.
4)Tian, Y., Yang, C., Shang, S., Cai, Y., Deng, X., Zhang, J., Shao, F., Zhu, D., Liu, Y., Chen, G., Liang, J.*, Sun, Q.*, Qiu, Z.*, and Zhang, C.* (2017) Loss of FMRP impaired hippocampal long-term plasticity and spatial learning in rats. Front. Mol. Neurosci. 10: 269.
5)Yao X, Wang X, Hu X, Liu Z, Liu J, Zhou H, Shen X, Wei Y, Huang Z, Ying W, Wang Y, Nie YH, Zhang CC, Li S, Cheng L, Wang Q, Wu Y, Huang P, Sun Q*, Shi L*, Yang H*. Homology-mediated end joining-based targeted integration using CRISPR/Cas9. Cell Research, 2017,27(6):801-814.
6)Zhen Liu, Yijun Cai, Qiang Sun. Genome editing of monkey. Methods in Molecular Biology, Published on 01 Jan 2017.
7)Zuo, E., Cai, Y., Li, K., Wei, Y., Wang, B., Sun, Y., Liu, Z., Liu, J., Hu, X., Wei, W., Huo, X., Shi, L., Tang, C., Liang, D., Wang, Y., Nie, Y., Zhang, C., Yao, X., Wang, X., Zhou, C., Ying, W., Wang, Q., Chen, R., Shen, Q., Xu, G., Li, J., Sun, Q.*, Xiong, Z.* and Yang,H.* (2017)  One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs. Cell Research (2017) 27:933–945. 
8)Zhen Liu, Xiao Li, Jun-Tao Zhang, Yi-Jun Cai, Tian-Lin Cheng, Yan Wang, Chen-Chen Zhang, Yan-Hong Nie, Wen-Jie Bian, Ling Zhang, Jian-Qiu Xiao, Bin Lu1, Yue-Fang Zhang, Xiao-Di Zhang, Xiao Sang, Jia-Jia Wu, Xiu Xu, Zhi-Qi Xiong, Feng Zhang, Xiang Yu, Neng Gong, Wen-Hao Zhou, Qiang Sun,*, Zilong Qiu,* Autism-like behaviors and germline transmission of transgenic monkeys expressing human MeCP2 .Nature,2016,530:98-102.
9)Zhen Liu, Yan-Hong Nie, Chen-Chen Zhang, Yi-Jun Cai, Yan Wang, Hui-Ping Lu, Yu-Zhuo Li, Cheng Cheng, Zi-Long Qiu, Qiang Sun*. Generation of macaques with sperm derived from juvenile monkey testicular xenografts. Cell Research, 2016,26:139-142.
10)Zhen Liu#, Xue Zhou#, Ying Zhu#, Zhi-Fang Chen, Bin Yu, Yan Wang, Chen-Chen Zhang, Yan-Hong Nie, Xiao Sang, Yi-Jun Cai, Yue-Fang Zhang, Tian-Lin Cheng, Chen Zhang, Wen-Hao Zhou, Qiang Sun,* Zilong Qiu,*. Generation of a monkey with MECP2 mutations by TALEN-based gene targeting. Neurosci Bull, June 1, 2014, 30(3): 381–386.
11)Hui Yang, Zhen Liu, Yu Ma, Cuiqing Zhong, Qi Yin, Chikai Zhou, Yijun Cai, Hanzhi Zhao, Hui Wang, Fan Tang, Yan Wang, Chenchen Zhang, Dongmei Lai, Mu-ming Poo, Dangsheng Li, Ying Jin, * Qiang Sun, * and Jinsong Li,*. Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes. Cell Research (2013) 23:1187–1200.
12)Qiang Sun*, Juan Dong, Wenting Yang, Yujuan Jin, Mingying Yang, Yan Wang, Philip L. Wang, and Yinghe Hu*, and Joe Z. Tsien*. Efficient reproduction of cynomolgus monkey using pronuclear embryo transfer technique. PNAS. 2008. 105(35): p. 12956-12960. 
13)Sun Q, Wei X, Feng J, Zhang R, Shen Q, Dong J, Jin Y, Dong S, Li H, Hu Y. Involvement of insulin-like growth factor-insulin receptor signal pathway in the transgenic mouse model of medulloblastoma. Cancer Sci, 2008. 99(2): p. 234-240.